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Intolerant Bodies: A Short History of Autoimmunity

by Warwick Anderson and Ian R Mackay Johns Hopkins University Press
Pub Date:
11/2014
ISBN:
9781421415338
Format:
Pbk 264 pages
Price:
AU$55.99 NZ$59.12
Product Status: Available in Approx 14 days
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Autoimmune diseases, which affect 5 to 10 per cent of the population, are as unpredictable in their course as they are paradoxical in their cause. They produce persistent suffering as they follow a drawn-out, often lifelong, pattern of remission, and recurrence. Multiple sclerosis, lupus, rheumatoid arthritis, and type 1 diabetes - the diseases considered in this book - are but a handful of the conditions that can develop when the immune system goes awry.
Intolerant Bodies is a unique collaboration between Ian Mackay, one of the prominent founders of clinical immunology, and Warwick Anderson, a leading historian of twentieth-century biomedical science. The authors narrate the changing scientific understanding of the cause of autoimmunity and explore the significance of having a disease in which ones body turns on itself. The book unfolds as a biography of a relatively new concept of pathogenesis, one that was accepted only in the 1950s.
In their description of the onset, symptoms, and course of autoimmune diseases, Anderson and Mackay quote from the writings of Charles Dickens, Edgar Allan Poe, Joseph Heller, Flannery Oconnor, and other famous people who commented on or grappled with autoimmune disease. The authors also assess the work of the dedicated researchers and physicians who have struggled to understand the mysteries of autoimmunity. Connecting laboratory research, clinical medicine, social theory, and lived experience, Intolerant Bodies reveals how doctors and patients have come to terms, often reluctantly, with this novel and puzzling mechanism of disease causation.

Foreword, by Charles E. Rosenberg
Introduction: Thinking Autoimmunity
1. Physiology with Obstacles
2. Immunological Thought Styles
3. A Sense of Unlimited Possibilities
4. The Science of Self
5. Doing Biographical Work
6. Reframing Self
Afterword: Becoming Autoimmune, or Being Not
Acknowledgments
Notes
Bibliography
Index

"With clarity, depth, and subtle provocation, Intolerant Bodies covers significant historical, biomedical, and philosophical ground to investigate and explain the aetiological paradox of autoimmune disease...discussions at biomedical science conferences, immunology seminars, and research colloquia will be all the richer if this book is widely circulated."

Warwick Anderson is an Australian Research Council laureate fellow and a professor in the Department of History and the Centre for Values, Ethics and the Law in Medicine at the University of Sydney. He is the author of The Collectors of Lost Souls: Turning Kuru Scientists into Whitemen, also published by Johns Hopkins.

Ian R Mackay is a research professor in the Department of Biochemistry and Molecular Biology at Monash University. He is the coauthor of Autoimmune Diseases: Pathogenesis, Chemistry, and Therapy and the coeditor of The Autoimmune Diseases, fifth edition.